Pharmacology
Ibogaine acts on multiple systems, including NMDA, kappa-opioid, sigma, and nicotinic receptors, and its metabolite noribogaine has a long half-life that extends its effects for days.
Iboga alkaloid · Oneirogen
Ibogaine
An alkaloid from the West African shrub Tabernanthe iboga, studied chiefly for interrupting opioid dependence — and carrying the most serious physiological risk profile in this archive.
History & context
Iboga is central to Bwiti ritual practice in Gabon. Interest in its anti-addictive properties emerged in the West in the 1960s and has continued largely outside regulated medicine.
Research landscape
Observational studies report reductions in withdrawal and craving; controlled trials remain scarce, and much of the practice occurs in unregulated clinics.
Risks
Ibogaine can cause QT prolongation and fatal cardiac arrhythmia. Deaths have been documented. Cardiac screening and medical supervision are considered essential.
Educational reference only. Nothing here is medical advice or a recommendation to use any substance.
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